Millets National Media Portal
Millets National Media Portal
Millets contain several biologically active compounds with demonstrated anti-tumorigenic properties. A 2023 paper published in Cureus described millets as a 'nutritional powerhouse with anti-cancer potential,' citing their ability to disrupt multiple cancer-promoting pathways.
Key anticancer mechanisms of millets include:
Apoptosis induction: Dietary fibers and plant protease inhibitors in millets trigger programmed cell death (apoptosis) in abnormal cells, preventing tumor growth.
Antiproliferative action: Bioactive peptides and polyphenols inhibit the proliferation of cancer cell lines, particularly in colon, breast, and liver cancers (in vitro studies).
Gut microbiota interaction: Prebiotic fiber feeds beneficial bacteria that produce short-chain fatty acids (SCFAs) such as butyrate, which has recognized anti-proliferative effects on colorectal cancer cells.
Tannins and phenolic acids: 3-deoxyanthocyanidins in sorghum are powerful anti-oxidative compounds linked to reduced cellular oxidative DNA damage.
Anti-inflammatory pathway suppression: Quercetin, ferulic acid, and protocatechuic acid in millets suppress NF-κB and COX-2 inflammatory pathways implicated in cancer initiation.
Foxtail millet and colorectal cancer: Research shows foxtail millet may reduce colitis-associated colorectal cancer severity through STAT3 pathway modulation.
Note: Most evidence is from in vitro and animal studies; large-scale human RCTs are still needed to establish definitive anticancer dosages.
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